Hand-to-Hand Combat

Hand-to-Hand Combat is a possible primary Skill you can level up during gameplay.
It's starting value is $30+3*Strength+1*Endurance+1*Intelligence+1*Luck$

It can be leveled up to 250%.

Each % increases your hit chance with Hand-to-Hand Combat. After 150%, you unlock weapon perks for Hand-to-Hand Combat weapons, every 25%. This means you get your first weapon perk unlocked at 150%, then at 175%, 200%, 225%, with the last one unlocking at 250% - making it quite beneficial to get it all the way up to 250%, if you are primarily using Hand-to-Hand Combat.